Cilia Ectocytosis

← Back to the Portfolio

Cover proposal for Cell

December 2016.

In this manuscript, Nachury et al describes how signaling receptors dynamically exit cilia upon activation of signaling pathways such as Hedgehog. They found that when activating G protein coupled receptors (GPCRs) fail to undergo BBSome-mediated retrieval from cilia back into the cell, they concentrate into membranous buds at the tips of cilia before release into extracellular vesicles named ectosomes.

The illustration depicts a digger mining a cilia mountain for those membranous buds with signaling receptors (crystals inside the rock).

Photoshop

 

Cilia Ectocytosis

Similar Projects

CAR T cell Therapy for Gliomas

CAR T cell Therapy for Gliomas

Nature Medicine, May 2018 Volume 24, Issue 5 Diffuse midline gliomas (DMGs) with the histone H3 K27M mutation are fatal pediatric tumors. In this issue, Michelle Monje and colleagues report […]

lncRNA Nuclear Enrichment Signals

lncRNA Nuclear Enrichment Signals

EMBO Journal, 15 March 2018 Volume 37, Issue 6 lncRNA Nuclear Enrichment Signals by Chinmay Shukla, Philipp Maas, John Rinn et al: High-throughput identification of RNA nuclear enrichment sequences. RNA […]

Organism-level analysis of vaccination

Organism-level analysis of vaccination

Cover proposal for Cell October 2017 The image in form of a mandala is a representation of diverse tissue and organs that are involved in immune response to vaccination forming […]