In this manuscript, Nachury et al describes how signaling receptors dynamically exit cilia upon activation of signaling pathways such as Hedgehog. They found that when activating G protein coupled receptors (GPCRs) fail to undergo BBSome-mediated retrieval from cilia back into the cell, they concentrate into membranous buds at the tips of cilia before release into extracellular vesicles named ectosomes.
The illustration depicts a digger mining a cilia mountain for those membranous buds with signaling receptors (crystals inside the rock).
Nature Medicine, May 2018 Volume 24, Issue 5 Diffuse midline gliomas (DMGs) with the histone H3 K27M mutation are fatal pediatric tumors. In this issue, Michelle Monje and colleagues report […]
Cover proposal for Cell October 2017 The image in form of a mandala is a representation of diverse tissue and organs that are involved in immune response to vaccination forming […]