lncRNA Nuclear Enrichment Signals

← Back to the Portfolio

EMBO Journal, 15 March 2018
Volume 37, Issue 6

lncRNA Nuclear Enrichment Signals by Chinmay Shukla, Philipp Maas, John Rinn et al: High-throughput identification of RNA nuclear enrichment sequences. RNA function presents the same problem of deciphering ancient hieroglyphics (inscribed Rosetta stone); it functions as a hieroglyphic rather than a word based lexicon in protein coding genes. Towards decoding RNA nuclear enrichment sequences for lncRNAs we developed a massively parallel RNA assay (MPRNA) to identify functional RNA domains. We identified several RNA domains that are sufficient for nuclear localization including a C-Rich motif across domains.

Photoshop

lncRNA Nuclear Enrichment Signals

Similar Projects

CAR T cell Therapy for Gliomas

CAR T cell Therapy for Gliomas

Nature Medicine, May 2018 Volume 24, Issue 5 Diffuse midline gliomas (DMGs) with the histone H3 K27M mutation are fatal pediatric tumors. In this issue, Michelle Monje and colleagues report […]

Organism-level analysis of vaccination

Organism-level analysis of vaccination

Cover proposal for Cell October 2017 The image in form of a mandala is a representation of diverse tissue and organs that are involved in immune response to vaccination forming […]

Gene profiling reveals gene networks and interactions

Gene profiling reveals gene networks and interactions

Cell, February 23, 2017 Volume 168, Number 5 In this issue, Wang et al. conducted genome-wide CRISPR-Cas9 screens to identify essential genes across a panel of cancer cell lines. Global […]