Modeling human evolution in mice: An adaptive variant of EDAR drives pleiotropic changes in mice and humans.
The image shows human footprints merging into mouse prints, as the mouse moves across a map of East Asia. The human variant, EDAR370A, arose approximately 30,000 years ago in Central China and spread through East Asia and Native America. Researchers generated a mouse model that mimics the evolution of this variant to further study novel targets of the EDAR370A mutation.
Nature Medicine, May 2018 Volume 24, Issue 5 Diffuse midline gliomas (DMGs) with the histone H3 K27M mutation are fatal pediatric tumors. In this issue, Michelle Monje and colleagues report […]
Cover proposal for Cell October 2017 The image in form of a mandala is a representation of diverse tissue and organs that are involved in immune response to vaccination forming […]