Viruses signal their presence to the immune system when they activate membrane and cytosolic receptors. In this issue, Chevrier et al. (pp. 853–867) uncover 35 antiviral signaling regulators, including 19 new members, involved in Toll-like receptor (TLR) pathways. In particular, they find that Polo-like kinases (Plks) are shared components of well-established antiviral pathways. The cover image depicts these antiviral-sensing pathways as a radar system in a dendritic cell that scans for new intruders using intracellular pathways with Plks. Artwork by Sigrid Knemeyer.
Nature Medicine, May 2018 Volume 24, Issue 5 Diffuse midline gliomas (DMGs) with the histone H3 K27M mutation are fatal pediatric tumors. In this issue, Michelle Monje and colleagues report […]
Cover proposal for Cell October 2017 The image in form of a mandala is a representation of diverse tissue and organs that are involved in immune response to vaccination forming […]