Volume 24, Issue 5
Diffuse midline gliomas (DMGs) with the histone H3 K27M mutation are fatal pediatric tumors. In this issue, Michelle Monje and colleagues report that CAR-T cells targeting the disialoganglioside GD2 are capable of killing DMG cells in preclinical models, offering hope for clinical translation of this immunotherapy. The cover depicts a tiger attacking hyenas, which do not naturally coexist in the same geographic region, to represent an exogenously introduced CAR-T cell attacking glioma cells.
Illustrator and Photoshop