Gene profiling reveals gene networks and interactions


February 23, 2017

Volume 168, Number 5

In this issue, Wang et al. conducted genome-wide CRISPR-Cas9 screens to identify essential genes across a panel of cancer cell lines. Global analysis of gene essentiality patterns uncovered correlations between functionally related gene sets - a set towards elucidating the functional organization of human cells. The cover illustration is an homage to Fritz Kahn's depiction of man as a machine. Each room within the cellular factory depicts a process in which co-essential gene sets were identified. The Cas9 protein is outlined on the tiles of the floor.
Please click here to view the cover on the journal's website.

Pen & ink and Photoshop