21 October 2017
Volume 137, No. 3
Connor Emdin, Amit V. Khera
Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.
"Role of NOS3 and GUCY1A3in nitric oxide signaling. Endothelial nitric oxide synthase, encoded by the gene NOS3, generates nitric oxide in the vascular endothelium. Nitric oxide acts as a signaling molecule to activate soluble guanylyl cyclase, a heterodimeric protein with one subunit encoded by the gene. Cyclic guanosine monophosphate produced by soluble guanylyl cyclase then activates downstream signaling molecules, leading to vasodilation, blood pressure lowering, inhibition of platelet aggregation and other cardiometabolic effects."