Critical regulators of Th17 cell pathogenicity


December 3, 2015

Volume 163, Issue 6

Th17 cells play key roles in immune defense and tissue homeostasis but can also become pathogenic and induce autoimmunity. Gaublomme et al. (pp. 1400–1412) use single-cell genomics to reveal the cellular circuit that regulates Th17 cell pathogenicity, and Wang et al. (pp. 1413–1427) show that CD5L acts as a molecular switch that alters lipid metabolism to regulate Th17 function.
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